Personalized Medicine

Feb 24, 2013|

The Roswell team discusses the new Center for Personalized Medicine

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Automatically Generated Transcript (may not be 100% accurate)

This is Roswell. Rookie by Roswell Park Cancer Institute. European opinion -- your total options you're hosed him -- and welcome back to rise wellness are continuing conversation. In comprehensive look at all aspects of cancer care treatment diagnosis and research from a comprehensive source we. Roswell Park Cancer Institute here in Buffalo, New York. Good morning until my anger and today we're talking about personalized medicine and what it means and his doctor Johnson I think we'll point out and then all three in the room today. This really is not only present but a big part. Of the future and it referenced doctor Johnson that's doctor Candice Johnson deputy director here at Roswell park. Cancer institute thank you that decadence have for being here thank you it's a pleasure to be exciting times for -- -- yeah really exciting always on the cutting edge and we're gonna really get to what that means in in just a moment. With us to his doctor Karl Morris and executive director of Roswell as. New center for personalized. Medicine you might hear them refer to along the way as. CPM doctor Morrison thanks for being here. Thank you -- we've we've talked about this before and a couple of radio. Shows that now orderly formally engaging. -- went public recently it an exciting no press briefing in news conference and a lot of funding behind this project in a lot of community support so I look forward to hearing more from you thanks for being here. And -- you brought with you today doctor Lisa Rodriguez director of community engagement resource within the new senator. An accurate -- -- welcome to the microphones and mine are to be here yet and you are leading up a charge that we're -- here about it's it's really important in this whole. Personalized medicine. Charge to make sure that you know the community is represented as a whole level -- more that coming up. All right thank you so much doctor Johnson ancestor for personalized medicine it's a it's a mouthful. Unless I think some of it is indicative of what it is but I think is that the community and myself don't know exactly what it is what is the center for personalized medicine here Roswell. Well on colleges is out in the forefront of this but personalized medicine really relates to diseases many many diseases because. What it says is is that. Your disease may have a certain signature. To it that that. Specifies it totally TU and what that means is is when you have breast cancer. There may be certain markers in your particular tumor that distinguish it from any other tumor. -- any other breast tumor. And many times some of the treatments and therapies that we use. May not take into account that specificity. That you're certain tumor has. And so personalized medicine is the search for these specific markers on New York. Cancer whatever that cancer may be so that we can better design treatment approaches. Two that cancer. Also. If you think about if we could know these specific little markers that may be on your tumor. We could may be detect them sooner. We could may be diagnosed them better and so the whole area personalized medicine is based around that. And genetics or genomics is where we are beginning with this. Using genetics as that specific. Marker. For your particular -- you know this might be a broad stroke but years ago. Someone had cancer. They get treated you know with with the best known care to state -- it might have been similar you know if you're treatment might be similar to my treatment might be similar to. Doctor Morrison's treatment but what you're telling me now is that the three of us. Are equal anymore -- treat you differently from me from him. Yes. And and it all depends. On. -- the signature that your tumor might have. And end. -- you know your genetic code orange the things that make you human and make all of us human IR. It's a series and there there are billions of these genes and and in each one of ourselves. But tumors. And today we note and just a little bit about this. We've identified. A handful maybe -- thirty genes. That today can predict what treatment may be best for you. And so it it's. Not only being able to provide that cutting edge today treatment. And diagnosis. For our patients but also to look for what are the other genes that are out there that we don't know about. What are other genes that may be on a breast cancer that says you need this drug vs drug and this is also dependent on the drugs that are available so. Right now -- handful of genes that we have their only. Handful of certain drugs that target those genes. But believe me the pharmaceutical industry and our nation as in oncology. Are looking for all these new and novel agents that can help to target cancer better. Brussels always really been on the forefront in this issue I remember years ago when I when I started. Working with you folks in in in presenting these programs I did you know awful on tour of of the campus and -- can take some time in and of itself. One of the -- I visited was that that genetics -- in in the participation in the Human Genome Project and I thought wow. That's like the future that's like. Well that's not the future really knows this -- -- this is the president and the future now I mean you why it's so important why is Russell really taken grasp of this personalized. Madison in genomics and and now really running the ball on the field. Well this is this is the future for Madison this is where -- going on college you think is maybe in the forefront of this because. There's a little bit known about a oncology there are some drugs out there but you know cardiovascular disease diabetes. That the prospects for personalized medicine are endless and it was really. Are desired to again end to this in a big way so that we could contribute and make an impact. For our patients here in western new York and across the country in so. I think that what we're starting left here in at Roswell park because -- cancer institute is oncology. But the basis of what we're doing and hopefully. This will be taken up at UB and other places around. Buffalo to expand this to diseases outside oncology. -- and I wanna come back Q a little bit in there and find out how this all came to -- is this this is not an easy undertaking it took a lot of resources and funding and backing. Not only here Roswell park but from our corporate community so we'll find out. More about that in in just that doctor Morrison you're leading the charge here is that if the executive director of this new. Senator for personalized. Madison how's -- gone good again thank you feel very well been been busy later challenges. You know I read a quote in some of that preparation materials here if you recited the sequence of your DNA allowed into a pretty good clip. It would take -- twelve years. That's correct and -- and in that context. In all this information that we generate in this center for personalized medicine. It it takes a lot of computing power and it was. It's it's really relevant to state that in the first week that the senator was up and running full time we generated more data. They never existed in the history of Roswell park since its inception in 18100 in one week. And all that data that exists today that shows you how much this is the data driven process. And you've got a lot of high tech equipment under your belt and at the sepia right Yasser takes a lot of high tech equipment takes a lot of highly trained. Professionals has been a big investment from for miles apart input from both capital expenditure and that the so we can -- all of your DNA or just part -- okay. And there's parts of your DNA that are more important than other parts of your the entire -- we think more important. In today's world you while we're talking earlier about genes right. And cancer is considered to be a disease that genes. And genes only make up about 1%. All of that the united and one numbers sales. 99% of it is we don't really know what all book. Parts -- it's supposed to be doing that if we wanted to sequence that one part. We can do that really in one day. If we want to do all 100% of your DNA it's gonna take is a week or more. But -- consider that -- used to take years and now we're doing and we keep we -- while it. And depending on what you are dealing with in a patient. Determines what part of that sequence you're looking looking for a second -- and get some really good example like today take lung cancer. Right yeah how much of lung cancer we relating to these -- say we deliver personalized medicine to -- cancer patient. Today we could we can almost narrow that down to twelve -- okay. And we used to being we've been looking to -- one of those teams wanted to tab. And it would take each task would take -- they're too and you put the whole process together and often takes a month. Now we just push all that into one test and you do it no matter for a few hours. Okay you've got. Three really important research projects underway. You might have more of a three that we're gonna focus focus on today can you can you walk me through a couple of them and then I know doctor. Rodriguez is gonna jump in here and talk about another. Yes -- let me talk about the first two enormously Arthur curious talk about the. The third but the first two there really are we're trying to say can we can we as raw hole -- and into -- go out and lead the field. In the Fannie what are some of these new therapies that we should begin for patience for the first former looking at is breast cancer. And were looking at breast cancer in the fact that. Most women are given the choice of two types of therapy for breast cancer either and to cycling -- they're peace or -- platinum -- they're peace. And which there'd be a woman is offered when she has breast cancer for the most part a flip of a cooling. Who were trying to say is which one of -- should we be offering you if you respond to and recycling based chemotherapy. In this study. Then that's what you should be having but if your genetic makeup says you should be taking so it's platinum. We should switch to another type of there so we're entering into a big study like that it's gonna take at least a year or two to have any significant conclusions but. We feel you know reasonably confident with the technology and all the the investment we put in this will be able to get some parents in -- area. The other area were looking at his bladder cancer in my bladder cancers for two reasons one is most. Over half of the patients to present bladder cancer present with diseases throughout their body. And really are no effective treatments it's a very -- very dismal outcome. We're trying to say are we can can be found some new machines. In bladder cancer we can give you -- in there before okay. In any other set of bladder cancer that working with with western or urology. Is there is a component of bladder cancer. It occurs. More as a disease that creates a significant. Changing your lifestyle it's called superficial bladder cancer. And not necessarily that it kills patients. But it's a huge cost of our health care Canada also for the patient and has that disease. It's significant changes or his third third. The quality of life for them the rest of their life. The -- that's a very calm and disease. We're trying to -- that disease been studied almost virtually none but we're trying to reach out and say let's study that disease because it's common. It really affects a lot of our patients them reach an avid community with. Question or urology in doing that study. Filled it out reaching the community which is -- Are the senator personalized medicine nothing. Leases directly to what doctor Rodriguez is doing in this third project a right you are listening to -- -- really exciting stuff today we are talking about personalized medicine. As doctor Karl Morris an executive director of Roswell new center for personalized. Medicine here on the Roswell campus earlier we heard from doctor Candice Johnson the deputy director of Roswell park. Here in Buffalo, New York in now with us is doctor Lisa Rodriguez. Director of community engagement resource within the -- center and doctor Rodriguez. It's important to -- me in this research to be represented of the of the entire community not just one. Or a majority -- you know one segment of the population tell me about this project that you're heavily involved it. Absolutely. -- it's extremely important to be inclusive and -- for search and have. A good effort at diversity. Roswell park and would say is probably at the forefront. Involve mean disparate communities are underserved communities. I'm especially at think racial communities and -- diverse in terms of genetic studies and genetic research has related to cancer. Minorities tend to be under represented. In a lot of biomedical science for surge but especially soul and genetic or search so this third project. It's really. A multi pronged effort and gaining education and out there and outreach and awareness around this type of research. It's a very layered resurgence so it's something that is not necessarily commonly known out there in the community sold the education component is huge. And that and secondly I've trained. Folks the opportunity to participate -- -- our interest in making participation convenient and with that power we have a mobile unit that we are able to take out into the community. And what are you asking these folks to do -- looking for 600 people in the -- what are you asking them to do. These are 600 healthy volunteers and by that we mean that they're not patients of the cancers -- And we are asking -- and to first be educated and learn about it through the education component. And and voluntarily. They're able to donate blood sample and so this community. Project is focused on. Collection of blood samples from a broad range of the western new York community and that blood sample is made up of about three tubes applied. And that's all it is is a blood sample and I think people get real scared about what you know when he hear about this type protesting. And there are a little intimidated it's simply a blood sample and you know most of us if not hall have gone through that. Share. I think. With the parent of the issue around a collection is just kind of some of the essence of the education component house to. Demystify -- search and that aspect and in terms of what why the blood is being collected. What the samples are four. And sang along with the blood sample we also collect epidemiological. Data so there's a survey data. To get that people's behaviors nutrition and exercise so lifestyle habits to help -- also give broader information and is an uphill battle -- you finding it difficult to. Get people to commit to this. In all honesty in some of the pilot projects that we've been getting house and some of the piloting of the program. I've been pleasantly surprised people are very excited they're very. Encouraged to learn about says and the fact that they are being included. I think in the past. Different parts of it can -- have felt that they hadn't known about seems. Going -- as -- research institute in Seoul to learn about this project into it have the education component. Along with -- opportunity to participate in making it clear that it is. It is voluntary. But also old. That the diversity aspect why we're collecting why it's important to have this broad range. So that more lean forward in this future search where including every one. Really gets people thinking and soul we've been encouraged to ask the participation that we've seen thus far. Karrie welcome back to you a little bit later in if anybody's interested in. Participating finding out how they can or interest hitting getting that mobile. Unit into there particular community you can tell us how. How they can be accomplished doctor Johnson everything we just talked about here -- we're with both doctor Morrison doctor Rodriguez. Based on something Roswell has been doing for a long long time and it's testing right that's exactly right. We have. It currently and then when it was first available and established. Testing for some of these molecular markers whenever they were available so. We have documented record in this and what we're doing now -- -- just expanding and that's. To you know this whole. Area -- is exploding in science there's so many new discoveries. Every on ecology meeting talks about. Some other association with some gene and certain drug -- certain prognosis so. We want to be right in the forefront of this. You know the the way we have been able to achieve this was through the help of Governor Cuomo and this was if you remember a year and a half ago Governor Cuomo. It's divided up the stage and said we would like to listen guys. Different areas of the state for economic development. And he. The -- Western New York mobilized. At stake were forward gifts. And awards if you will and 109 dollars and so Western New York mobilized they were. Folks representing all aspects. Tourism. Trade education and health. And life sciences. Infrastructure all kinds of things manufacturing. And Roswell park put in an application doctor trump and -- Submitted this application. To. Provide and to get funds to provide the infrastructure. For us to establish a center. Western New York was successful. I traveled to Albany where we present this to the governor's folks. They've liked what they heard. Western New York got one of the hundred million dollar. Awards and Roswell park -- five point one million of that money. To establish infrastructure to buy the sequel answers to by the computing clusters to make -- renovations in the labs to be able to. Carry this out. We at that time. As you can imagine and doctor Morrison said this. Is. The computing capacity -- capabilities. To do these things. Electronically. Is a challenge. And so we needed a partner partner that could help us develop the software. The tools that we would need not only to analyze this -- But also to provide. The infrastructure and software for the physician that was ordering this test. And how'd they get those results back and how they understand what they have just now ordered and received. And so we've partnered with Computer Task Group CTG. That is headquartered here in buffalo there an incredible organization. We. Jim bolt who heads that organizations that -- press conference. But doctor Morrison and Acura agree Rigas and I work very closely with my colts and enjoy Hoffman and many others CTG. They have contributed only financially to these efforts. But it'll actually as well and so the prospect for our joint partnership is very positive and we're excited about what's ahead. Let's go back to the actual. Testing aspect of all of this in in in this studio through the years and I -- Russell park. There's been a lot of genetic testing. That has been. Happening. This isn't the same right doctor Morrison so I mean we need to clarify that to senator for personalized menace Mullen has a research -- But also as a clinical arm okay in the political arm will be offering tennis. -- in a plea is certified sending that are approved by the new York state department of health. And -- also want him to says that we do not. See our clinical effort. Just restricted to rock park -- to -- into our community western York upstate New York. As we are today the only such center outside of New York City in the State of New York. We -- the only senator who has they seek answers in a plea is certified laboratory and is developing tests that are going to be. Approved by the new York state department of -- How does the clinical side work -- do we talked to lie here about the research projects that you and doctorate reais or are are spearheading. That did describe for me to clinical side so so let's say that and an oncologist meets what -- lung cancer patient right. And he wants to know right I have. Five or six -- particular target they're featured targeted means that. As we -- stating earlier that not every person today of lung cancer is gonna get the same treatment. If you can get one of these targeted here it is more -- -- less toxic team. And to -- and you're more likely to respond to treatment and you are with conventional -- -- right so the oncologists would. He goes to his electronic medical record -- look up that pace electronic medical record and order this new sequencing test against that patient's tumor. And and it would take a few days from that result would come back -- patients' medical record. And not only would it come back which is what the results board would also come back with a link to all the knowledge. About what these results are because there's so much knowledge that you cannot expect one person to manage all that so. Begin this goes back to all the data and informatics and while we need all these various. Resources to do this process so truly is personalizing and individuals. Cancer treatment that exactly. And again this is not just for Roswell park you you know this is this is. Information they can be shared outside of the senate again and and -- in the way this process is being put together about all the different people that have always expertise and referred to as informatics. You could order this test in Rochester Binghamton -- oleander for the onion. And it would look just like the -- if you -- in Iran for part the result would come back this thing. The order would be the same so we are really it's our intent to reach out to the community into you know two groups spread this. This this technology around all of upstate New York heart doctor Rodriguez he did a great job. Of explaining. You can project that you're spearheading in in what you're asking of you know potentially 600 folks to do. If anyone out there is interested in in participating in that is it's something that they can reach out to Roswell and get involved with. I'm Kenny request to get that mobile van brought to a particular location and if so how. Sure we have a couple of things going on we have. Outreach that we're doing with partners that are established through our office of cancer health disparities are searched. And we are doing programs that involve education and Indiana and we're also doing community events -- and can be requested. And we can allow for folks to get a look at it and -- Without having the education component involved as well. They can contact us through the office of cancer health disparities for search. We have two different health educators that are working ET. Clark her -- who is conducting our English programming. As well as she -- Cologne who was offering our programs and Spanish. All right and doctor Johnson were looking for a name right and in in a way to fund that that. How we'd love to have thought we'd love to name the center -- yes all right and if anyone out there in the community and that that in the business community. Anyone listening his interest in finding out more about that you can call in the seven point six area code 845. 13055451305. You know is doctor Morrison mentioned this is the only place in. In you know the state for upstate. Well there their and this is the only place in upstate their places Sloan Kettering and -- In New York City then then and the New York genome -- is doing some of these things. We are the first conference of cancer sooner or the first. Have anyone to try to get clear certification until bundled these tests together in the way doctor Morrison describes yes. And actually if you look around the country. We're really at the forefront of that as well. In every one in this community wants Roswell to be here when we need it when we needed for ourselves or family or friends. And it's been here and and always will be here there are many senators like this around around the country. This is another reason that the -- or another example of how it really solidifies Roswell. And so one of the foremost. Comprehensive -- use that word cancer. Not only treatment but I think sometimes we forget about his community the research side. And these are important it's what distinguishes us from other places is that weird just not. And I I don't mean to minimize that treating people with cancer. We're trying not only to treat you were trying to cure you with the state of the yard cutting edge resurgent and technology that we have our fingertips and and that's our goal is we want to we wanna get rid of this disease we want to and so the only way to do that history search. We always say can treat us the best today what to do it tomorrow we've got to have the resurgence act right. Okay thank you for being here this is really exciting stuff and I think we've only just touch the the tip of what the three of you in the entire team near Roswell park. Have going on with this center for personalized medicine it's exciting stuff and I think. The community has already learned some that we need to learn a lot more doctor Johnson thank you so much use -- doctor Candice Johnson she is the deputy director here at Roswell park. And doctor Lisa Rodriguez thank you so much for your time thank you and good luck in that project and we've got a lot to. Due to you know get that that sample size out there and we appreciate it and we'll give up the phone number in just a moment that's doctor Lisa. Rodriguez director of community engagement resource within. The new CPM and doctor Karl Morris and as always thank you for being here appreciate it. They can hopefully in about a year from now we can come back and have the ultimate challenger we impacting -- and let's revisit this and in see the exciting stuff that. You all have achieved here Russell park. Doctor Carl Morrison executive director of Roswell new. Center for personalized medicine it really is an exciting project and facility here. On the Roswell campus if you'd like to call Braswell and find out more information you can do so toll free at 877 ask our PCI. 8772757724. You can also find out more by visiting web site. -- listen to Roswell this Sunday mornings at 630 young WB yeah. -- by Roswell Park Cancer Institute European opinion for your total options on line at Roswell this god of war. And and -- do. Then.